Cardiometabolic risk in young women with obesity. Primary data
DOI:
https://doi.org/10.52556/2587-3873.2024.5(102).07Keywords:
obesity, leptin/adiponectin ratio, insulin resistanceAbstract
Obesity is a chronic disease with extensive health consequences. Its prevalence is constantly increasing, including among children and young people. In this study we assessed the cardiometabolic risk and its correlation with leptin/adiponectin ratio in obese young women. We enrolled 72 apparently healthy women, comprising 36 with normal weight (BMI ≤ 25 kg/m²) and 36 with obesity (BMI ≥ 30 kg/m²). The mean age was 34.1±5.6 years. Clinical and paraclinical parameters were studied: body mass index (BMI), waist and hip circumference, waist-hip ratio, blood presure, serum level of glucose, insulin, leptin, adiponectin, total cholesterol, HDL cholesterol, LDL cholesterol. Compared to normal weight women, obese women have had significantly higher levels of leptin, insulin and blood glucose (p < 0.001). But the level of adiponectin was lower (p < 0.001). The leptin/adiponectin ratio had a positive correlation with BMI, waist circumferince, waist-hip ratio, blood glucose, insulinemia, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), LDL cholesterol and negative correlation with HDL cholesterol in the group of obese women. Research results revealed higher cardiometabolic risk in young women with obesity. The leptin/adiponectin ratio is in direct correlation with this risk, being a good predictor of insulin resistance.
References
1. WHO, Obesity and overweight, key facts. Disponibil: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
2. JIN, X., QIU, T., LI, L., et al. Pathophysiology of obesity and its associated diseases. In: Acta Pharm Sin B. 2023, nr. 13(6), pp. 2403-2424, https://doi.org/10.1016/j.apsb.2023.01.012
3. TOMACINSCHII, Angela. Obezitatea - problemă prioritară în sănătatea publică. În: Curierul Medical, 2012, nr. 3(327), pp. 356-359. ISSN 1875-0666.
4. YASHI K, DALEY SF. Obesity and Type 2 Diabetes. [Updated 2023 Jun 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
5. EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). In: J Hepatol. 2024 Jun 5:S0168-8278(24)00329-5. Epub ahead of print. PMID: 38851997. https://doi.org/10.1016/j.jhep.2024.04.031
6. CREWE, C., AN, Y.A., SCHERER, P.E. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. In: J Clin Invest. 2017, nr. 127(1), pp. 74-82. https://doi.org/10.1172/JCI88883
7. OBRADOVIC, M., et al. Leptin and Obesity: Role and Clinical Implication. In: Front Endocrinol (Lausanne). 2021, nr. 12:585887. https://doi.org/10.3389/fendo.2021.585887
8. SCHWARTZ, M.W., et al. Obesity Pathogenesis: An Endocrine Society Scientific Statement. In: Endocr Rev. 2017, nr. 38(4), pp. 267-296. https://doi.org/10.1210/er.2017-00111
9. NGUYEN, T.M.D. Adiponectin: Role in Physiology and Pathophysiology. In: Int J Prev Med. 2020, Sep 3;11:136. https://doi.org/10.4103/ijpvm.IJPVM_193_20
10. KHORAMIPOUR, K., et al. Adiponectin: Structure, Physiological Functions, Role in Diseases, and Effects of Nutrition. In: Nutrients. 2021, nr. 13(4):1180. https://doi.org/10.3390/nu13041180
11. FRÜHBECK, G., et al. Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation. In: Nutrients. 2019, nr. 11(2): 454. https://doi.org/10.3390/nu11020454
12. FRÜHBECK, G., CATALÁN, V., RODRÍGUEZ, A., GÓMEZAMBROSI, J. Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. In: Adipocyte. 2018, nr. 7(1), pp. 57-62. https://doi.org/10.1080/21623945.2017.1402151
13. COELHO, M., OLIVEIRA, T., FERNANDES, R. Biochemistry of adipose tissue: an endocrine organ. In: Arch Med Sci. 2013, nr. 9(2), pp. 191-200. https://doi.org/10.5114/aoms.2013.33181
14. AHIMA, R.S., FLIER, J.S. Adipose tissue as an endocrine organ. In: Trends Endocrinol Metab. 2000, nr. 11(8), pp. 327-32. https://doi.org/10.1016/S1043-2760(00)00301-5
15. MASOOD, B., MOORTHY, M. Causes of obesity: a review. In: Clin Med (Lond). 2023, nr. 23(4), pp. 284-291. https://doi.org/10.7861/clinmed.2023-0168
16. KHANNA, D., WELCH, B.S., REHMAN, A. Pathophysiology of Obesity. [Updated 2022 Oct 20]. In: StatPearls[Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
17. KANG, E.S., et al. Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea. In: Metabolism. 2005, nr. 54(2), pp. 206-11. https://doi.org/10.1016/j.metabol.2004.08.014
18. ZHAO, S., KUSMINSKI, C.M., SCHERER, P.E. Adiponectin, Leptin and Cardiovascular Disorders. In: Circ Res.2021, nr. 128(1), pp. 136-149. https://doi.org/10.1161/CIRCRESAHA.120.314458
19. STERN, J.H., RUTKOWSKI, J.M., SCHERER, P.E. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. In: Cell Metab. 2016, nr. 23(5), pp. 770-84. https://doi.org/10.1016/j.cmet.2016.04.011
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
