Cryptococcal meningitis in patients with HIV/AIDS
Keywords:
Cryptococcosis, Cryptococcus neoformans, cryptococcal meningitis, HIV/AIDS infectionAbstract
An important infectious illness for worldwide public health is cryptococcosis. The estimated one-year mortality of people living with HIV who receive care for cryptococcal meningitis (СM) is 70% in low-income countries versus 20–30% for high-income countries [13]. In order to study the peculiarities of the evolution of cryptococcal meningitis we conducted a retrospective-descriptive study. All 14 patients included in study during the years 2018-2023 were admitted to the dermatological and Communicable Diseases Hospital in Chisinau. The results of the study suggest that the CD4 level below 20 cells is associated with the unfavorable outcome of MC in patients with HIV/AIDS.
References
1. Abassi M., Boulware D., Rhein J. Cryptococcal Meningitis: Diagnosis and Management Update. Current Tropical Medicine Reports. 2015;2(2):90-99. https://doi.org/10.1007/s40475-015-0046-y
2. CDC. Preventing Deaths from Cryptococcal Meningitis | Fungal Diseases | CDC. www.cdc.gov. Published November 24, 2020. https://www.cdc.gov/fungal/cdc-and-fungal/cryptococcal-meningitis.html.
3. Concha-Velasco F., González-Lagos E., Seas C., Bustamante B. Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis. PLoS One. 2017;12:e0174459. https://doi.org/10.1371/journal.pone.0174459
4. Feldmesser M., Tucker S., Casadevall K. A. Intracellular parasitism of macrophages by Cryptococcus neoformans. Trends in Microbiology. 2001;9(6):273-278. https://doi.org/10.1016/S0966-842X(01)02035-2
5. Huffnagle G., Lipscomb M., Lovchik J., Hoag K., Street N. The role of CD4+ and CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol. 1994;55:35-42. https://doi.org/10.1002/jlb.55.1.35
6. Momin M., Webb G. The Environmental Effects on Virulence Factors and the Antifungal Susceptibility of Cryptococcus neoformans. International Journal of Molecular Sciences. 2021;22(12):6302. https://doi.org/10.3390/ijms22126302
7. Montoya M., Magwene P., Perfect J. Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review. Journal of Fungi. 2021;7(4):260. https://doi.org/10.3390/jof7040260
8. Park B., Wannemuehler K., Marston B., Govender N., Pappas P.,; Chiller T. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23(4):525-530. https://doi.org/10.1097/QAD.0b013e328322ffac
9. Rajasingham R., Smith R., Park B., Jarvis J., Govender N., Chiller T. et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17:873-81. https://doi.org/10.1016/S1473-3099(17)30243-8
10. Skipper C., Abassi M., Boulware D. Diagnosis and Management of Central Nervous System Cryptococcal Infections in HIV-Infected Adults. Journal of Fungi. 2019;5(3):65. https://doi.org/10.3390/jof5030065
11. Spadari C., Wirth F., Lopes L., Ishida K. New Approaches for Cryptococcosis Treatment. Microorganisms. 2020;8(4). https://doi.org/10.3390/microorganisms8040613
12. Stafford S., Brofsky K., Mcvay R. et al. Cryptococcus: Screening for Opportunistic Infection among People Living with HIV/AIDS.; 2012. https://www.cdc.gov/fungal/pdf/at-a-glance-508c.pdf.
13. WHO, 2022. Guidelines for diagnosing, preventing and managing criptococcal disease among adults, adolescents and children living with HIV.
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