Updates in the management of non-Hodgkin’s lymphomas: epidemiological and socio-economical profile

Abstract

The increase of incidence in the working-age population, commonly late diagnosis and signifi cant levels of disability in non-Hodgkin’s lymphomas (NHL) may be considered as key topics of clinical hematooncology and public health management. An analytical study was performed – the narrative review of the literature under the form of a synthesis article. To achieve this goal, we searched by keywords for medical scientifi c publications in the database Google Search, PubMed, Z-library, NCIB, Medscape, Hinari. The incidence of NHL in Western countries is 14–19 new cases per 100000 of population (4% of all malignancies). In both sexes, the incidence of NHL corresponded to the country-related Human Development Index. The incidence rates at the beginning of the last decade varied signifi cantly by geographic region, being higher in males. In 2016, 2017, 2018, 2019 and 2020 the incidence of NHL (C82 - C85; C88, С96) in Moldova was 5.9, 6.7, 5.1, 6.8 and 5.1, exceeded the respective index in other hematological malignancies, but manifested the decreasing tendency. NHL caused 6.8 million DALYs (disability-adjusted life-years) in 2016, with 98% coming from lost-life years and 2% from years lived with disabilities. Th e primary determinants of costs were hospitalizations (aggressive NHL – 44%, indolent NHL – 50% of total costs) and outpatient visits.