Primary biliary cirrhosis associated with ovarian cancer - clinical case
Keywords:
primary biliary cholangitis, ovarian cancerAbstract
Primary biliary cholangitis (PBC) formerly known as primary biliary cirrhosis is an important but uncommon disease that predominantly affects women in their 50s and 60s. PBC is considered a multifactorial autoimmune disease that probably arises from a combination of environmental and genetic factors. The disease is chronic and often progressive, leading to end-stage liver disease and its associated complications. The goal of lifelong therapy is to prevent progressive liver disease and to relieve disease-related symptoms that reduce the patient’s quality of life. The given clinical case is of diagnostic and evolutionary interest. Initially, 10 years ago, the diagnosis fell within the classic clinical-paraclinical picture of PBC, for which the patient was monitored and received treatment. In 2017, the oncomarker CEA-125 was increased, but the MRI of the pelvis revealed only involutional changes of the internal genital organs. For the last 2 years, due to the COVID-19 pandemic, the patient avoided visiting the doctor and investigations, the patient’s condition worsened. In 2022 CT of the small pelvis detected a massive malignant tumor of the right ovary, with liver cirrhosis, ascites, splenomegaly, portal hypertension, periportal lymphadenopathy, esophageal varices, periumbilical varices.
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