Drug-induced hemolytic anemia
Keywords:
hemolytic anemia, immune hemolytic anemia, drug-induced hemolytic anemiaAbstract
More than 130 drugs are documented to be responsible for hemolytic anemias. The groups and drugs most frequently reported as in charge of hemolytic anemias include: antimicrobial drugs (antibiotics, synthetic chemotherapy, antimalarials, antituberculous), nonsteroidal anti-inflammatory drugs and analgesics (diclofenac, paracetamol, ibuprofen), antineoplastics (fludarabine, oxiplatin, carboplatin, chlorambucil, ribavirin), cardiovascular (methyldopa, hydrochlorothiazide, amlodipine, enalapril, ramipril, perindopril, etc.), gastrointestinal (omeprazole, etc.), hormonal agents (metformin, hydrocortisone), contrast agents (iohexol, iomeprol, isopac). Mechanisms of hemolytic anemias include: formation of immune complexes (drug-antibody complexes on erythrocyte membrane) or autoantibodies (induction of anti-erythrocyte antibodies), drug absorption induced by haptens (high doses of penicillin)
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