Sindromul MOSH – o nouă viziune a hipogonadismului dobândit

Victoria Ghenciu; Arian Iurii; Ion Dumbraveanu; Mariana Creciun; Emil Ceban

doi:10.52556/2587-3873.2024.5(102).22

Authors

Victoria Ghenciu Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0009-0000-5001-5137
Arian Iurii Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0000-0003-1436-5230
Ion Dumbraveanu Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0000-0003-1114-2189
Mariana Creciun Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0000-0002-4771-5703
Emil Ceban Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0000-0002-1583-2884

DOI:

https://doi.org/10.52556/2587-3873.2024.5(102).22

Keywords:

MOSH, hypogonadism, obesity, male sexual reproductivedysfunction, infertility

Abstract

Functional male hypogonadism in association with obesity has recently been defined as secondary obesity-induced hypogonadism – MOSH syndrome. Сlinical manifestations are explained by two important mechanisms: testosterone deficiency and excess adipose tissue. Synthesis of 50 articles predominantly of the last 10 years from databases: Google Scholar, PubMed, Research Gate, Wiley Online Library, Health Data Science using keywords – „MOSH”, „hypogonadism”, „obesity”, „male sex-reproductive dysfunction”, „infertility”. The prevalence of MOSH in the general population is 45% and correlates positively with the degree of obesity. Multifactorial pathogenetic mechanisms include lipotoxicity, suppression of the hypothalamic-pituitary-gonadal axis, leptinresistance, hyperestrogenemia, oxidative stress, proinflammatory status, metabolic insulinoresistance and endotoxemia, sleep apnea, genetic and epigenetic changes, etc, with major impact on male sexual-reproductive health. Treatment strategy includes decrease in body mass, which can relieve the symptoms of androgen deficiency, improve metabolic profile and fertility. MOSH is a subtype of functional hypogonadism with reversible potential with substantial weight loss.

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