Drug-induced thyroid gland dysfunctions
Keywords:
drug-induced hypothyroidism, drug-induced hyperthyroidism, drugs and thyroid, drugs and thyroid hormonesAbstract
In recent decades a separate interest has been the study of the influence of drugs on thyroid function.The selection and analysis of scientific papers in the Pubmed database was carried out regarding the disorders of the function of the thyroid gland caused by drugs. It was found that the drugs are able to affect the function of the thyroid gland at the level of the hypothalamus-pituitary-thyroid axis, the synthesis, release, activation, metabolism and elimination of thyroid hormones, as well as to influence the effects of thyroid hormones at the cellular and systemic level. A wide range of drugs (iodine preparations, antiepileptics, antituberculosis drugs, monoclonal antibodies, glucocorticoids, antitumor drugs, estrogens, immunostimulatory cytokines, antacids, bile acid sequestrants, amiodarone, heparin, furosemide, etc.), have been identified, which can influence the function of the thyroid gland through different mechanisms. Drugs may induce subclinical or clinically manifest hypothyroidism or thyrotoxicosis. When examining the patient with suspected thyroid pathology, it is necessary to collect the anamnesis to highlight the drugs used as possible etiologic factors of thyroid dysfunction.
References
1. AL-ALUSI, M.A., DU L., LI N. et al. Metformin Does Not Suppress Serum Thyrotropin by Increasing Levothyroxine Absorption. In: Thyroid. 2015 nr. 25(10), pp.1080-4. https://doi.org/10.1089/thy.2015.0211
2. BACINSCHI, N., VUDU, L., BACINSCHI-GHEORGHITA, S., BACINSCHI, A. Hipotiroidismul indus de preparatele antituberculoase. În: Buletinul Academiei de Știinţe a Moldovei. Știinţe Medicale. 2022, nr. 3(74), pp. 200-204. ISSN: 1857-0011. https://doi.org/10.52692/1857-0011.2022.3-74.40
3. BENVENGA, S. L-T4 Therapy in the Presence of Pharmacological Interferents. In: Front Endocrinol (Lausanne). 2020 nr. 11, 607446. https://doi.org/10.3389/fendo.2020.607446
4. BHATTACHARYA, S., GOYAL, A., KAUR, P. et al. Anticancer Drug-induced Thyroid Dysfunction. In: Eur Endocrinol. 2020 nr.16(1), pp.32-39. https://doi.org/10.17925/EE.2020.16.1.32
5. BORAN, G., SEHEULT, J. Drug effects on the hypothalamic-pituitary-thitoidaxis and thyroid hormone concentration. In: CPD Bulletin Clinical Biochemistry. 2013, nr. 11(3), pp. 92-98.
6. BURCH, H.B. Drug Effects on the Thyroid. In: N Engl J Med. 2019, nr. 381, pp. 749-61. https://doi.org/10.1056/NEJMra1901214
7. CHENG, L.T., CHUNG, C.H., PENG, C.K. et al. Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study. In: Front Med (Lausanne). 2022 nr. 9, 900858. https://doi.org/10.3389/fmed.2022.900858
8. FROLDI, G. View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences. In: Pharmaceuticals (Basel). 2024 nr.17(4), 478. https://doi.org/10.3390/ph17040478
9. KARAVITI, D., KANI, E.R., KARAVITI, E. et al. Thyroid disorders induced by immune checkpoint inhibitors. In: Endocrine. 2024 nr. 12.
https://doi.org/10.1007/s12020-024-03718-2
10. LI, Q., ZHANG, Z., FANG, J. Hormonal Changes in nr. Women with Epilepsy. In: Neuropsychiatr Dis Treat.2024 nr. 20, pp.373-388. https://doi.org/10.2147/NDT.S453532
11. MENG, X., XU, S., CHEN, G. et al. Metformin and thyroid disease. In: J Endocrinol. 2017 nr. 233(1), R43-R51. https://doi.org/10.1530/JOE-16-0450
12. MEIER, C.A., BURGER, A.C. Effects of Drugs and Other Substances on Thyroid Hormone Synthesis and Metabolism. In: Braerman LE, Utiger RD, editors. Warner and Ingbar's The Thyroid. 9. Philadelphia: Lippincott Raven; 2005. pp. 229-246.
13. MIYAKE, ZENSHI, ISHII, KAZUHIRO, TAMAOKA, AKIRA. Hypothyroidism induced by phenytoin and gabapentin: A Case Report. In: Medicine. 2018, nr. 97(43), e12938, https://doi.org/10.1097/MD.0000000000012938
14. QUIROZ-ALDAVE, J.E., DURAND-VÁSQUEZ, M.D.C., GAMARRA-OSORIO, E.R. et al. Drug-induced
hypothyroidism in tuberculosis. In: Expert Rev Endocrinol Metab. 2024 nr. 19(3), pp. 199-206. https://doi.org/10.1080/17446651.2024.2307525
15. PAPPA, T., ALEVIZAKI, M. Metformin and thyroid: an update. In: Eur Thyroid J. 2013 nr.2(1), pp.22-28. https://doi.org/10.1159/000346248
16. RIZZO, L.F., MANA, D.L., SERRA, H.A. Drug-induced hypothyroidism. In: Medicina buenos aires. 2017, nr. 77, 5. PMID: 29044016.
17. SANDE, C.M., TONDI RESTA, I., LIVOLSI, V.A. The Thyroid Pathologist Meets Therapeutic Pharmacology. In: Endocr Pathol. 2023 nr. 34(1), pp.48-56. https://doi.org/10.1007/s12022-023-09749-1
18. SURKS, M.I. Drug interactions with thyroid hormones. In: UpToDate. 2024.
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