Diareea cronică la pacienții cu infecția clostridium difficile în asociere cu COVID-19
Cuvinte cheie:
COVID-19, SARS-CoV-2, infecția C.difficile, diareea cronică, factori de riscRezumat
Infecția Clostridium difficile (ICD) este o complicație a infecții COVID-19 ,cauzată de alterarea microbiomului în cadrul administrării pe termen lung a antibioticelor cu spectru larg. Au fost analizate studiile contemporane privind influența și interacțiunea pandemiei COVID-19 asupra diareii cronice cauzate de Clostridium difficile (C. difficile). Administrarea excesivă a antibioticelor la pacienții cu COVID-19 provoacă modificarea eubiozei microbiotei din tractul respirator și gastrointestinal. Alterarea compoziției microbiotei fecale la pacienții cu COVID-19 este asociată cu creșterea numărului agenților patogeni oportuniști și diminuarea comensalelor benefice. C. difficile este un organism patogen care este responsabil pentru majoritatea cazurilor de diaree asociată antibioticelor. Administrarea empirică a preparatelor antibacteriene și antiinflamatorii nesteroidiene, istoric recent de expunerea la asistență medicală, prezența comorbidităților precum boli cardiovasculare sau diabet asociate cu vârsta peste 65 de ani sunt factori predispozanți pentru ICD la pacienții cu COVID-19.
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