Deviations in the content of neurotransmitters amino acids in patients with chronic hepatopathies
DOI:
https://doi.org/10.52556/2587-3873.2023.4(97).20Keywords:
amino acids, Neurotransmitters, glycine, gammaaminobutyric acid, glutamate, aspartateAbstract
Some amino acids are neurotransmitters. These include glycine (Gly), gamma-aminobutyric acid (GABA), glutamate (Glu), and aspartate (Asp). The liver is an important organ for the metabolism of amino acids. Materials and methods. It was examined 24 patients with chronic hepatopathy: 12 patients with chronic HBV infection (group I) and 12 patients with hepatic steatosis (group II), the control group (CG) consisted of 12 practically healthy individuals. Quantitative determination of Asp, Glu, Gly and GABA in blood serum was carried out using liquid chromatography. Results. In most patients with chronic hepatopathy Gly and Asp levels were within the regional norms, GABA levels were higher, and Glu levels were below the reference values. In I-st group of patients the level of Gly was 18.76±1.45, GABA - 0.83±0.06, Asp - 5.56±0.97, and Glu - 6.34±0.70 mcM/ dL. In II-nd group: the level of Gly was 22.37±0.91, GABA 0.77±0.03, Asp - 5.16±0.74, and Glu - 7.87±1.47 mcM/dL. In CG: the level of Gly was 22.93±2.21, GABA - 0.55±0.06, Asp - 2.69±0.45, and Glu - 12.46±1.92 mcM/dL. Conclusion. A violation of neurotransmitter amino acids metabolism is found in chronic hepatopathy. A decrease in glycine and glutamate was observed in patients’ blood serum, with an increase in GABA and aspartate. These disorders are most profound in individuals with chronic viral infection B.
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