Clostridium difficile infection in patients with COVID-19 treated in CMH „St. Archangel Mihail”
Keywords:
COVID-19, Clostridioides difficile infectionAbstract
Coronavirus disease (COVID-19), which is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARSCoV2), predominantly includes pulmonary symptoms; however, <10% of cases also include gastrointestinal events, including abdominal pain, diarrhea, and vomiting. Among hospital-acquired infections, Clostridioides difficile infection (CDI) represents one of the most important global public health threats. CDI infection is the most common cause of antibiotic-associated diarrhea. This accounts for 15-25% of all episodes of antibiotic-associated diarrhea. The frequency of co-infections with Clostridium difficile in patients with COVID-19 increased during the pandemic. The aim of the study was to evaluate the frequency, clinical features and risk factors associated with CDI in patients with COVID-19 treated in CMH „Sfântul Archangel Mihail”, that confirmed 35 ICD positive COVID-19 patients; 21 were women and 14 - men; the average age was 68 years ±2,75, ranging from 40 to 97 years. The study demonstrated that age older than 60 years, long-term antibacterial treatment with a broad spectrum of action, immunosuppressives, the presence of comorbidities, treatment with proton pump inhibitors were risk factors for the occurrence of CDI in patients with COVID-19.
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