Development of an Instrument to Explore the Level of Knowledge and Perceptions of Family Physicians Regarding Personalized Medicine

Authors

Keywords:

questionnaire, Personalized Medicine, family doctors

Abstract

Personalized medicine in primary health care is being implemented slowly and faces multiple barriers. In this context, it is important to understand family physicians’ level of knowledge, perceptions, and training needs in this field. The aim of the study was the development and primary validation of a questionnaire to explore family physicians’ level of knowledge and perceptions regarding personalized medicine. The questionnaire was developed in accordance with COSMIN principles, based OR including on a review of the scientific literature and the definition of thematic components. The items were generated based on the scientific literature and the defined conceptual framework. Content validation included consultation with experts, and pretesting with family physicians allowed adjustment to the clarity and relevance of the questions. The final version of the questionnaire contains 48 items organized into thematic components: level of knowledge and familiarity, understanding of the foundations of personalized medicine, acceptance and perceived value, barriers and determinants of implementation, professional role and educational needs, and sociodemographic data. The items include single-choice, multiple-choice, Likert-scale, and true/ false questions, with open-ended options where necessary. The exploratory nature and coverage of multiple areas of interest make the questionnaire suitable for establishing a baseline regarding personalized medicine. The instrument enables identification of barriers and facilitating factors for the adoption of personalized medicine and may support the development of education programs tailored to family physicians’ needs and implementation strategies appropriate to the local context.

References

1. Wijayanti, E., Mahardhika, Z.P. Implementation of precision medicine in primary care: A struggle to improve disease prevention. Korean Journal of Family Medicine. 2024;45(6):359-361. https://doi.org/10.4082/kjfm.24.0165

2. Schaibley, V.M., et al. Limited genomics training among physicians remains a barrier to genomics-based implementation of precision medicine. Frontiers in Medicine. 2022;9:757212. https://doi.org/10.3389/fmed.2022.757212

3. Mikat-Stevens, N.A., Larson, I.A., Tarini, B.A. Primary-care providers' perceived barriers to integration of genetics services: a systematic review of the literature. Genetics in Medicine. 2015;17(10):797-806. https://doi.org/10.1038/gim.2014.101

4. Council of the European Union. Concluziile Consiliului privind medicina personalizată pentru pacienți. Brussels; 2015. Available from: https://eur-lex.europa.eu

5. Haga, S.B., Kim, E., Myers, R.A., Ginsburg, G.S. Primary care physicians' knowledge, attitudes, and experience with personal genetic testing. Journal of Personalized Medicine. 2019;9(2):29. https://doi.org/10.3390/jpm9020029

6. Ong, C.S., et al. General practitioners' experience, attitudes and needs on clinical genetic services: a systematic review. Family Medicine and Community Health. 2022;10:e001624. https://doi.org/10.1136/fmch-2021-001515

7. Pot, M., Spalletta, O., Green, S. Precision medicine in primary care: how GPs envision "old" and "new" forms of personalization. Social Science & Medicine. 2024;358:117259. https://doi.org/10.1016/j.socscimed.2024.117259

8. Gusila, I., Topa, A., Zarbailov, N., Lungu, N., Curocichin, G. Personalised medicine implementation in low- and middle-income countries. In: Sontea V., Tiginyanu I., Railean S. (eds). 6th International Conference on Nanotechnologies and Biomedical Engineering (ICNBME 2023). IFMBE Proceedings; 2023;92:411-420. https://doi.org/10.1007/978-3-031-42782-4_44

9. Carroll, J.C., et al. Informing integration of genomic medicine into primary care: an assessment of current practice, attitudes, and desired resources. Frontiers in Genetics. 2019;10:1189. https://doi.org/10.3389/fgene.2019.01189

10. Lemke, A.A., et al. Primary care physician experiences with integrated population-scale genetic testing: a mixed-methods assessment. Journal of Personalized Medicine. 2020;10(4):165. https://doi.org/10.3390/jpm10040165

11. Skinner, S.J., Clay, A.T., McCarron, M.C.E., Liskowich, S. Interpretation and management of genetic test results by Canadian family physicians: a multiple-choice survey of performance. Journal of Community Genetics. 2021;12(3):479-484. https://doi.org/10.1007/s12687-021-00511-w

12. Chase, D.A., Baron, S., Ash, J.S. Clinical decision support and primary care acceptance of genomic medicine. In: Studies in Health Technology and Informatics. 2017;245:700-703. https://doi.org/10.3233/978-1-61499-830-3-700

13. Bravo, M.L., et al. Incorporating genomic medicine into primary-level health care for chronic non-communicable diseases in Mexico: a qualitative study. International Journal of Health Planning and Management. 2020;35(6):1426-1437. https://doi.org/10.1002/hpm.3053

14. Lemke, A.A., et al. Primary care physician experiences with integrated pharmacogenomic testing in a community health system. Pharmacogenomics. 2017;14(5):389-400. https://doi.org/10.2217/pme-2017-0036

15. Blitstein, J.S., et al. Integration of personalized medicine into primary care clinics: a path to make large-scale population genomics studies successful. Genetics in Medicine. 2022;24(3):S324. https://doi.org/10.1016/j.gim.2022.01.540

16. Smith, D.M., et al. Assessment of primary care practitioners' attitudes and interest in pharmacogenomic testing. Pharmacogenomics. 2020;21(15):1085-1094. https://doi.org/10.2217/pgs-2020-0064

17. Zebrowski, A.M., et al. Qualitative study of system-level factors related to genomic implementation. Genetics in Medicine. 2019;21(7):1534-1540. https://doi.org/10.1038/s41436-018-0378-9

18. Hauser, D., et al. Views of primary care providers on testing patients for genetic risks for common chronic diseases. Health Affairs. 2018;37(5):793-800. https://doi.org/10.1377/hlthaff.2017.1548

19. Hamilton, J.G., et al. Primary care providers' cancer genetic testing-related knowledge, attitudes, and communication behaviors: a systematic review and research agenda. Journal of General Internal Medicine. 2017;32(3):315-324. https://doi.org/10.1007/s11606-016-3943-4

20. Hansen, J.M., Nørgaard, J.D.S.V., Kälvemark Sporrong, S. A systematic review of pharmacogenetic testing in primary care: attitudes of patients, general practitioners, and pharmacists. Research in Social and Administrative Pharmacy. 2022;18(8):3230-3238. https://doi.org/10.1016/j.sapharm.2021.12.002

21. DeLuca, J., et al. Toward personalized medicine implementation: survey of military medicine providers in pharmacogenomics. Military Medicine. 2020;185(3-4):336-340. https://doi.org/10.1093/milmed/usz419

22. Beans, J.A., et al. Perspectives on precision medicine in a tribally managed primary care setting. AJOB Empirical Bioethics. 2020;11(4):246-256. https://doi.org/10.1080/23294515.2020.1817172

23. Heck, P.R., Meyer, M.N. Population whole exome screening. Medical Clinics of North America. 2019;103(6):1077-1092. https://doi.org/10.1016/j.mcna.2019.08.004

24. Stefanicka-Wojtas, D., Duda-Sikuła, M., Kurpas, D. Personalised medicine - best practices exchange and implementation in European regions. Medical Science Pulse. 2020;14(1):1-8. https://doi.org/10.5604/01.3001.0014.2475

25. Admas, T., Banjaw, A. Healthcare professionals' knowledge, attitudes and future expectations towards personalized medicine. Personalized Medicine. 2021;18(5):483-490. https://doi.org/10.2217/pme-2020-0185

26. Pelletier, S., et al. Survey of primary care physicians' views about breast and ovarian cancer screening for BRCA1/2 non-carriers. Journal of Community Genetics. 2020;11(2):205-213. https://doi.org/10.1007/s12687-019-00438-3

27. Yu, M.W.C., et al. Preparing genomic revolution: attitudes, clinical practice, and training needs in delivering genetic counseling in primary care. Molecular Genetics & Genomic Medicine. 2021;9(7). https://doi.org/10.1002/mgg3.1702

28. Croitoru, C., Ciobanu, E., Ferdohleb, A. Validarea chestionarului: cunoștințe, atitudini și practici privind antibiotico-rezistența la medici. Revista de Științe ale Sănătății din Moldova. 2022;3(84):4-15.

29. Caliga, I., et al. Assessment of neurologists' knowledge, attitudes, and practices regarding heat stress during heatwaves. One Health & Risk Management. 2025;6(4):52-67. https://doi.org/10.38045/ohrm.2025.4.05

Published

2026-06-28

Issue

Section

Articles

How to Cite

[1]
Gușilă, I. 2026. Development of an Instrument to Explore the Level of Knowledge and Perceptions of Family Physicians Regarding Personalized Medicine. Public Health Economy and Management in Medicine. 1(106) (Jun. 2026), 70–78.

Similar Articles

1-10 of 462

You may also start an advanced similarity search for this article.