Echocardiographic-Based Phenotyping of Right Ventricular Dysfunction After Pulmonary Embolism
Keywords:
pulmonary embolism, echocardiography, NTproBNP, right ventricular dysfunction, PhenotypingAbstract
Evaluating right ventricular (RV) dysfunction after acute pulmonary embolism (PE) is essential for the long-term management of patients with persistent symptoms, and developing algorithms focused on assessing this dysfunction has gained significant interest in recent years. The current study evaluated 110 patients 6 months post-event who had suffered a PE, using a multimodal approach that integrates clinical status (NYHA, PVFS), NT-proBNP levels, and conventional and advanced (3D and speckle-tracking) echocardiographic parameters. The results demonstrated that using composite criteria, such as the ABC phenotype (reflecting the RV–pulmonary circulation axis) and the RV+ profile (specific for systolic dysfunction), allows for efficient clinical triage. Implementing this multimodal framework enables phenotypic differentiation of subjects, identifying risk markers for Chronic Thromboembolic Pulmonary Hypertension (CTEPH) that require high-resolution investigations, as opposed to profiles that only require rehabilitative management.
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