Health-related quality of life in patients with gastric cancer: case-control study
DOI:
https://doi.org/10.52556/2587-3873.2022.2(93).02Keywords:
quality of life, health, gastric cancerAbstract
Cancer has a great impact on the quality of life in terms of physical, mental, and social functions and affects the quality of life of patients. The aim of the study was to compare healthrelated quality of life (HRQL) in patients with gastric cancer to that of the general population and to analyze the impact of gastric cancer on quality of life by all subscale components. The matched pair case-control study was performed. The Case group of 50 patients with gastrointestinal cancer was compared with the control group of 50 study participants without cancer, to whom the EORTC QLQ-C30 questionnaire was similarly applied. The results showed a decrease of HRQL in many aspects for patients with cancer compared to those without cancer. According to functional scales, role and emotional functioning were found lower in patients with cancer by more than 20 points, qualified as major clinical interest change (p < .001). According to the symptoms scale, only in the occurrence of pain do we observe major HRQL decline in patients with cancer (p < .001). Financial difficulties were also identified for a major decrease in HRQL in cancer patients (p <.001). It is concluded that patients with cancer report a lower HRQL predominantly related to the social and psychological aspects than to the cancer disease somatic conditions. In clinical care, it should be considered that the majority of cancer patients are quite concerned about their emotional and role functioning. Efforts to reduce these worries should be made in decision-making with clinicians while making care more patient-centered in order to improve their HRQL.
References
1. BRAY, Freddie, FERLAY, Jacques, SOERJOMATARAM, Isabelle, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. In: CA: A Cancer Journal for Clinicians [online]. 2018, 68(6), 394-424 [accessed. 2022-01-09]. ISSN 1542-4863. Available at: https://doi.org/10.3322/caac.21492
2. SUNG, Hyuna, FERLAY, Jacques, SIEGEL, Rebecca L., et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. In: CA: a cancer journal for clinicians [online]. 2021, 71(3), 209-249 [accessed. 2022-01-18]. ISSN 1542-4863. Available at: https://doi.org/10.3322/caac.21660
3. PENINA, Olga. Long-term trends in cancer mortality in the Republic of Moldova. In: One Health & Risk Management [online]. 2021, 2(4), 76-85 [accessed. 2022-01-07]. ISSN 25873458. Available at: https://doi.org/10.38045/ohrm.2021.4.07
4. TINTIUC, Dumitru, PENINA, Olga, RAEVSCHI, Elena, and OBREJA, Galina. Mortalitatea și speranța de viață în Republica Moldova în context european. Culegere de articole științifice consacrată aniversării a 90-a de la nașterea ilustrului medic și savant Nicolae Testemițanu. Chișinău, 2017, p. 314-319. 2017.
5. DAI, Z., LANG, W., YANG, H., et al. Validation of EORTC QLQ-OES18 for Chinese patients with esophageal cancer. In: Diseases of the Esophagus [online]. 2017, 30(10), 1-7 [accessed. 2021-12-24]. ISSN 14422050. Available at: https://doi.org/10.1093/dote/dox046
6. GENG, Hai mei, CHUANG, Dong mei, YANG, Fang, et al. Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis. In: Medicine (United States) [online]. 2018, 97(39) [accessed. 2022-01-05]. ISSN 15365964. Available at: https://doi.org/10.1097/MD.0000000000011863
7. MCCORMICK, Anna. Quality of life. Cerebral Palsy: A Multidisciplinary Approach, Third Edition [online]. 2018, 335-341 [accessed. 2022-01-09]. ISSN 0806-7511. Available at: https://doi.org/10.1007/978-3-319-67858-0_33
8. VAN LEEUWEN, Marieke, HUSSON, Olga, ALBERTI, Paola, et al. Understanding the quality of life (QOL) issues in survivors of cancer: Towards the development of an EORTC QOL cancer survivorship questionnaire. In: Health and Quality of Life Outcomes [online]. 2018, 16(1) [accessed. 2022-01-09]. ISSN 14777525. Available at: https://doi.org/10.1186/s12955-018-0920-0
9. ISHAQUE, S., KARNON, J., CHEN, G., NAIR R. and SALTER, A. B. A systematic review of randomized controlled trials evaluating the use of patient-reported outcome measures (PROMs). In: Quality of Life Research [online]. 2019, 28(3), 567-592 [accessed. 2022-01-09]. ISSN 15732649. Available at: https://doi.org/10.1007/s11136-018-2016-z
10. GIESINGER, Johannes M., LOTH, Fanny L.C., AARONSON, Neil K., et al. Thresholds for clinical importance were established to improve interpretation of the EORTC QLQ-C30 in clinical practice and research. In: Journal of Clinical Epidemiology [online]. 2020, 118, 1-8 [accessed. 2022-01-09]. ISSN 18785921. Available at: https://doi.org/10.1016/j.jclinepi.2019.10.003
11. THRESHOLDS_FOR_CLINICAL_IMPORTANCE_WERE_ESTABLISHED_TO_IMPROVE_INTERPRETATION_OF_THE_EORTC_QLQ_C30_IN_CLINICAL_PRACTICE_AND_RESEARCH.PDF
12. MUSORO, Jammbe Z., COENS, Corneel, FITENI, Frederic, et al. Minimally important differences for interpreting EORTC QLQ-C30 scores in patients with advanced breast cancer. In: JNCI Cancer Spectrum [online]. 2019, 3(3) [accessed. 2022-01-09]. ISSN 25155091. Available at: https://doi.org/10.1093/jncics/pkz037
13. RATJEN, Ilka, SCHAFMAYER, Clemens, ENDERLE, Janna, et al. Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: A German cohort study. In: BMC Cancer [online]. 2018, 18(1) [accessed. 2022-01-09]. ISSN 14712407. Available at: https://doi.org/10.1186/s12885-018-5075-1
14. HAGIWARA, Yasuhiro, SHIROIWA, Takeru, TAIRA, Naruto, et al. Mapping EORTC QLQ-C30 and FACT-G onto EQ-5D-5L index for patients with cancer. In: Health and Quality of Life Outcomes [online]. 2020, 18(1) [accessed. 2021-12-24]. ISSN 14777525. Available at: https://doi.org/10.1186/s12955-020-01611-w
15. AARONSON, Neil K., AHMEDZAI, Sam, BERGMAN, Bengt, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. In: JNCI: Journal of the National Cancer Institute [online]. 1993, 85(5), 365-376 [accessed. 2021- 12-27]. ISSN 0027-8874. Available at: https://doi.org/10.1093/jnci/85.5.365
16. NOLTE, S., G. LIEGL, M. A. PETERSEN, et al. General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States. In: European Journal of Cancer [online]. 2019, 107, 153-163 [accessed. 2022-01-09]. ISSN 18790852. Available at: https://doi.org/10.1016/j.ejca.2018.11.024
17. FAYERS P., AARONSON N., BJORDAL K., et al. EORTC QLQ-C30 Scoring Manual the EORTC QLQ-C30. Published by: European Organization for Research and Treatment of Cancer, Brussels, 2001. ISBN 2-9300 64-22-6.
18. OSOBA, David, RODRIGUES, George, MYLES, James, et al. Interpreting the significance of changes in health-related quality-of-life scores. In: Journal of clinical oncology: official journal of the American Society of Clinical Oncology [online]. 1998, 16(1), 139-144 [accessed. 2022-01-01]. ISSN 0732-183X. Available at: https://doi.org/10.1200/JCO.1998.16.1.139
19. FRÖJD, Camilla, LARSSON, Gunnel, LAMPIC, Claudia, and Louise VON ESSEN. Health related quality of life and psychosocial function among patients with carcinoid tumours. A longitudinal, prospective, and comparative study. In: Health and quality of life outcomes [online]. 2007, 5 [accessed. 2022-01-05]. ISSN 1477-7525. Available at: https://doi.org/10.1186/1477-7525-5-18
20. SKARSTEIN, Jon, AASS, Nina, FOSSÅ, Sophie D., SKOVLUND, Eva, and DAHL, Alv A. Anxiety and depression in cancer patients: relation between the Hospital Anxiety and Depression Scale and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire. In: Journal of Psychosomatic Research [online]. 2000, 49(1), 27-34 [accessed. 2021-12-27]. ISSN 0022-3999. Available at: https://doi.org/10.1016/S0022-3999(00)00080-5
21. MCKERNAN, M., D. C. MCMILLAN, J. R. ANDERSON, W. J. ANGERSON and R. C. STUART. The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastro-oesophageal cancer. In: British Journal of Cancer [online]. 2008, 98(5), 888-893 [accessed. 2021-12-24]. ISSN 00070920. Available at: https://doi.org/10.1038/sj.bjc.6604248
22. YI, Jean C. and SYRJALA, Karen L. Anxiety and Depression in Cancer Survivors. In: Medical Clinics of North America [online]. 2017, 101(6), 1099-1113 [accessed. 2022-01-05]. ISSN 15579859. Available at: https://doi.org/10.1016/j.mcna.2017.06.005
23. SHRESTHA, Anne, MARTIN, Charlene, BURTON, Maria, et al. Quality of life versus length of life considerations in cancer patients: A systematic literature review. In: Psycho-Oncology [online]. 2019, 28(7), 1367-1380 [accessed. 2022-01-09]. ISSN 10991611. Available at: https://doi.org/10.1002/pon.5054
24. PERRY, Laura M., HOERGER, Michael, SEIBERT, Katherine, et al. Financial Strain and Physical and Emotional Quality of Life in Breast Cancer. In: Journal of Pain and Symptom Management [online]. 2019, 58(3), 454-459 [accessed. 2022-01-05]. ISSN 18736513. Available at: https://doi.org/10.1016/j.jpainsymman.2019.05.011
25. VERMA, Vivek, SPRAVE, Tanja, HAQUE, Waqar, et al. A systematic review of the cost and cost-effectiveness studies of immune checkpoint inhibitors 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis. In: Journal for ImmunoTherapy of Cancer [online]. 2018, 6(1) [accessed. 2022-01-04]. ISSN 20511426. Available at: https://doi.org/10.1186/s40425-018-0442-7
26. KIM, Seon Ha, Min-Woo JO, Hwa-Jung KIM and Jin-Hee AHN. In: Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients [online]. 2012. Available at: http://www.hqlo.com/content/10/1/151 https://doi.org/10.1186/1477-7525-10-151
27. GIBSON, Eddie J., BEGUM, Najida, KOBLBAUER, Ian, et al. Economic evaluation of single versus combination immuno-oncology therapies: Application of a novel modelling approach in metastatic melanoma. In: ClinicoEconomics and Outcomes Research [online]. 2020, 12, 241-252 [accessed. 2022-01-09]. ISSN 11786981. Available at: https://doi.org/10.2147/CEOR.S238725
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