Efectele substanțelor auxiliare folosite în dopaj asupra funcţiei sexual-reproductive masculine

Mariana Creciun; Victoria Ghenciu; Iurii Arian; Constantin Tataru; Ion Dumbraveanu

Efectele substanțelor auxiliare folosite în dopaj asupra funcţiei sexual-reproductive masculine

Autori

Mariana Creciun Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ https://orcid.org/0000-0002-4771-5703
Victoria Ghenciu Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ https://orcid.org/0009-0000-5001-5137
Iurii Arian Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ https://orcid.org/0000-0003-1436-5230
Constantin Tataru Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ https://orcid.org/0009-0007-5059-6454
Ion Dumbraveanu Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“ https://orcid.org/0000-0003-1114-2189

Cuvinte cheie:

SARM, hormoni peptidici, agonişti beta2 adrenerigici, derivați ai aminoacizilor, inhibitori demiostatină, fertilitate

Rezumat

Utilizarea substanțelor farmacologice pentru îmbunătățirea performanței sportive este răspândită în sport și culturism. Dopingul implică substanțe precum steroizi anabolizanți, modulatori selectivi ai receptorilor de androgeni, hormonii peptidici, agoniștii beta-2 adrenergici. Deși sunt percepute ca alternative mai sigure la steroizii tradiționali, totuși, prezintă riscuri pentru sănătate, inclusiv asupra funcției reproductive masculine. A fost cercetată literatura de specialitate cu utilizarea bazelor de date electronice PubMed, Scopus și Google Scholar. Din 296 de articole publicate până în 2024, 30 incluse în studiu furnizau date despre efectele substanțelor asupra funcției sexual-reproductive. Deși modulatorii selectivi ai receptorilor androgenici nu prezintă efecte adverse notabile, precum steroizii, utilizarea lor în exces poate suprima producția endogenă de testosteron, alterând spermatogeneza. Hormonii peptidici, agoniștii beta-2 adrenergici pot deregla echilibrul hormonal, afectând axa hipotalamo-hipofizo-gonadală (HPG), suprimarea secreției de hormon luteinizant (LH) și foliculostimulant (FSH). Inhibitorii de miostatină și consumul excesiv de derivați ai aminoacizilor pot provoca dezechilibre hormonale și stres oxidativ, afectând calitatea materialului seminal. Substanțele auxiliare cu efect anabolizant utilizate în dopaj pot avea efecte adverse semnificative asupra sănătății reproductive masculine, precum suprimarea axei HPG, scăderea testosteronului și afectarea spermatogenezei. Sunt necesare studii suplimentare pentru a înțelege mecanismele exacte și impactul pe termen lung al acestor substanțe asupra sănătății reproductive.

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Descărcări

Publicat

14.04.2026

Număr

Nr. 5(102) (2024)

Secțiune

Articles

Licență

Această lucrare este licențiată în temeiul Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Cum cităm

[1]

Creciun, M. et al. 2026. Efectele substanțelor auxiliare folosite în dopaj asupra funcţiei sexual-reproductive masculine. Sănătate Publică, Economie şi Management în Medicină. 5(102) (Apr. 2026), 162–167.