Amniotic membrane transplantation in the management of cornal ulcers refractory to conventional treatment

Abstract

Assess the efficacy of amniotic membrane transplantation (AMT) to patients with refractory corneal ulcer and evaluate the benefits and limitations of AMT in the management of ocular surface pathology. A retrospective study was performed, which included 37 patients (37 eyes) diagnosed with corneal ulcer of various etiologies, refractory to conventional drug treatment. Satisfactory results were found in the vast majority of operated eyes. The amniotic membrane can be considered a successful alternative for the reconstruction of the ocular surface. Success rates of TMA differ depending on the etiology of the ulcer, with major efficacy in bacterial and herpetic ulcers on the one hand, and limited benefits in severe chemical burns and autoimmune pathologies on the other.