Sisteme tehnologice inovaționale în prelevarea și procesarea corneei

Autori

DOI:

https://doi.org/10.52556/2587-3873.2022.1(92).05

Cuvinte cheie:

celule endoteliale, mediu de cultură, presiune intraoculară, celule epiteliale, stroma, bioreactorq, bancă de ochi

Rezumat

Dispozitivele și instrumentariul folosite în prelevarea și procesarea corneei sunt și vor fi una din necesitățile folosite de Banca de ochi. Analiza aparatajului și instrumentariului modern pentru prelevarea și procesarea corneei necesită un progres tehnologic și informațional ce tinde să modernizeze toate tipurile de dispozitive pentru a spori calitatea corneei, ceea ce permite o stocare ex vivo mai îndelungată, menținând în același timp viabilitatea straturilor corneei la nivel epitelial, stromal și endotelial. Bioreactoarele sunt dispozitive complexe care mențin depozitarea corneei ex vivo care sunt mai aproape de norma fiziologică. Multe studii arată că aceste dispozitive direct sau indirect influențează activitatea celulelor.

Referințe

1. Resnikoff D., Pascolini D., Etyaale I., Kocur R., Pararajasegaram G.P., Pokharel S.P., Mariotti B. Global data on visual impairment in the year 2002. World Health Organization. 2004, 82, 844.

2. Armitage W. Interventions Implemented to Reduce the Risk of Transmission of Bacteria by Transfusion in the English National Blood Service. J. Transfus. Med. Hemoth. 2011, 38, 143. https://doi.org/10.1159/000330474

3. Roeck T., Hofmann J., Thaler S., Bramkamp M., BartzSchmidt K. U.,Yoeruek E., Rock D., Organ transplantation scandal influencing corneal donation rate. Arch. Clin. Exp. 2016, 254, 135. https://doi.org/10.1007/s00417-015-3119-7

4. Cociug, A., Macagonova, O., Cusnir, V. Jr., Cusnir, V., and Nacu, V. Evaluation of the endothelial cell regenerative proprieties of the cornea in the culture media. results and prospects. 4th International Conference on Nanotechnologies and Biomedical Engineering Proceedings of ICNBME-2019, September 18-21, 2019, 601-605. https://doi.org/10.1007/978-3-030-31866-6_107

5. Cociug, A., Olga, Macagonova, O., Nacu, V.: Patent. (MD) 1048. Device for cutting of the cornea. BOPI, nr. 6/2016, p.34.

6. Cociug, A., Olga, Macagonova, O., Nacu, V.: Patent number 1504 MD. Cornea fixation device. BOPI, nr. 2/2021, p.52.

7. Cociug, A., Olga, M., Nacu, V.: 1311 MD Device for corneal preservation and examination of endothelial cells of the cornea. BOPI, nr. 2/2019, p. 51.

8. Bryant, M.R., McDonnell, P.J. A triphasic analysis of corneal swelling and hydration control. J Biomech Eng. 1998; 120: 370-381. https://doi.org/10.1115/1.2798004

9. Massie, I., Levis, H.J., Daniels, J.T. Response of human limbal epithelial cells to wounding on 3D RAFT tissue equivalents: effect of airlifting and human limbal fibroblasts. Exp Eye Res. 2014; 127: 196-205. https://doi.org/10.1016/j.exer.2014.07.024

10. Kang, Y.G., Shin, J.W., Park, S.H., et al. Effects of flowinduced shear stress on limbal epithelial stem cell growth and enrichment. PLoS One. 2014; 9: e93023. https://doi.org/10.1371/journal.pone.0093023

11. Piehl, M., Gilotti, A., Donovan, A., DeGeorge, G., Cerven, D. Novel cultured porcine corneal irritancy assay with reversibility endpoint. Toxicol In Vitro. 2010; 24: 231-239. https://doi.org/10.1016/j.tiv.2009.08.033

12. Dikstein, S., Maurice, D.M. The metabolic basis to the fluid pump in the cornea. J Physiol. 1972; 221: 29-41. https://doi.org/10.1113/jphysiol.1972.sp009736

13. Hull, D., Green, K., Boyd, M., Wynn, H. Corneal endothelium bicarbonate transport and the effect of carbonic anhydrase inhibitors on endothelial permeability and fluxes and corneal thickness. Invest Ophthalmol Vis Sci. 1977; 16: 883-892.

14. Brunette, I., Nelson, L.R., Bourne, W.M. A system for long-term corneal perfusion. Invest Ophthalmol Vis Sci. 1989; 30: 1813-1822.

15. Tanelian, D.L., Bisla, K. A new in vitro corneal preparation to study epithelial wound healing. Invest Ophthalmol Vis Sci. 1992; 33: 3024-3028.

16. Thiel, M.A., Morlet, N., Schulz, D., et al. A simple corneal perfusion chamber for drug penetration and toxicity studies. Br J Ophthalmol. 2001; 85: 450-453. https://doi.org/10.1136/bjo.85.4.450

17. Zhao, B., Cooper, L.J., Brahma, A., et al. Development of a three-dimensional organ culture model for corneal wound healing and corneal transplantation. Invest Ophthalmol Vis Sci. 2006; 47: 2840-2846 https://doi.org/10.1167/iovs.05-1367

18. Elsheikh, A., Alhasso, D., Rama, P. Biomechanical properties of human and porcine corneas. Exp Eye Res. 2008; 86: 783-790. https://doi.org/10.1016/j.exer.2008.02.006

19. Hatami-Marbini, H., Etebu, E., Rahimi, A. Swelling pressure and hydration behavior of porcine corneal stroma. Curr Eye Res. 2013; 38: 1124-1132. https://doi.org/10.3109/02713683.2013.809769

20. Elsheikh, A., Wang, D., Brown, M., et al. Assessment of corneal biomechanical properties and their variation with age. Curr Eye Res. 2007; 32: 11-19. https://doi.org/10.1080/02713680601077145

21. Borderie, V.M., Baudrimont, M., Lopez, M., Carvajal, S., Laroche, L. Evaluation of the deswelling period in dextran-containing medium after corneal organ culture. Cornea. 1997; 16: 215-223. https://doi.org/10.1097/00003226-199703000-00015

22. Thuret, G., Manissolle, C., Campos-Guyotat, L., Guyotat, D., Gain, P. Animal compound-free medium and poloxamer for human corneal organ culture and deswelling. Invest Ophthalmol Vis Sci. 2005; 46: 816-822. https://doi.org/10.1167/iovs.04-1078

23. Albon, J., Tullo, A.B., Aktar, S., Boulton, M.E. Apoptosis in the endothelium of human corneas for transplantation. Invest Ophthalmol Vis Sci. 2000; 41: 2887-2893.

24. Gain, P., Thuret, G., Chiquet, C., et al. Value of two mortality assessment techniques for organ cultured corneal endothelium: trypan blue versus TUNEL technique. Br J Ophthalmol. 2002; 86: 306-310. https://doi.org/10.1136/bjo.86.3.306

25. Pai, V.C., Glasgow, B.J. MUC16 as a sensitive and specific marker for epithelial downgrowth. Arch Ophthalmol. 2010; 128: 1407-1412. https://doi.org/10.1001/archophthalmol.2010.268

26. Uchino, Y., Goto, E., Takano, Y., et al. Long-standing bullous keratopathy is associated with peripheral conjunctivalization and limbal deficiency. Ophthalmology. 2006; 113: 1098-1101. https://doi.org/10.1016/j.ophtha.2006.01.034

Descărcări

Publicat

19.04.2026

Număr

Secțiune

Articole

Cum cităm

[1]
Cociug, A. et al. 2026. Sisteme tehnologice inovaționale în prelevarea și procesarea corneei. Public Health Economy and Management in Medicine. 1(92) (Apr. 2026), 32–37. DOI:https://doi.org/10.52556/2587-3873.2022.1(92).05.

Articole similare

1-10 of 317

Puteți, de asemenea, începeți o căutare avansată de similaritate pentru acest articol.