Infecția cu clostridioides difficile: o provocare continue în domeniul sănătății publice
DOI:
https://doi.org/10.52556/2587-3873.2024.4(101).05Cuvinte cheie:
Clostridioidies difficile, pandemia COVID-19, long-COVID, antibiotice, dismicrobism intestinalRezumat
Acest studiu se concentrează pe analiza unui eșantion de 134 de pacienți, internați în cadrul IMSP SCBI ,,Toma Ciorbă”, cu diagnosticul de enterocolită prin Clostridioidies diffi cile în perioada martie 2020 – aprilie 2024. Scopul cercetării a fost de a evalua aspectele clinice, epidemiologice și de laborator ale cazurilor de CDI apărute în timpul pandemiei de COVID-19 cât și în perioada long COVID. Au fost aplicate următoarele metode de cercetare: documentară și matematică. S-a constat o creștere semnifi cativă în Republica Moldova a incidentței de CDI în perioda pandemică de Covid-19, a cazurilor de recidivă cu Clostridioidies diffi cile comparativ cu perioada anterioară pandemiei. Dezechilibrul microbiotei intestinale, apărut în urma terapiei îndelungate cu antibiotice, favorizează colonizarea cu C. diffi cile, precum și cu alte tipuri de fl oră patogenă.
Referințe
1. AKERLUND, Thomas, et al. Increased sporulation rate of epidemic Clostridium difficile. In: Journal of Clinical Microbiology [online]. 2018, nr. 46(4), pp. 1530 -1533. ISSN 2995-8539. https://doi.org/10.1128/JCM.01964-07
2. ALLEGRETTI, Jessica R. Prevalence and impact of Clostridioides difficile infection among hospitalized patients with coronavirus disease [online]. PubMed Central, Martie 2011. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114993/.
3. BAKER, Meghan A, et al. The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections. In: Clinical Infectious Disease [online]. 2022, nr. 74(10), pp. 1748-1754. ISSN 1058-4838. https://doi.org/10.1093/cid/ciab688
4. BALSELLS, Evelyn, et al. Global burden of Clostridium difficile infections: a systematic review and meta-analysis. In: Journal of Global Health [online]. Iunie 2019, nr. 9(1), [citat 05.07.2024] ISSN 2047-2986. https://doi.org/10.7189/jogh.09.010407
5. BROWN, Kevin, et al. Meta-Analysis of Antibiotics and the Risk of Community-Associated Clostridium difficile Infection. In: Antimicrobial Agents and Chemotherapy Journal [online]. 11 aprilie 2013, nr. 57(5), pp. 2326 - 2332 [citat 08.07.2024] ISSN 1098-6596. https://doi.org/10.1128/AAC.02176-12
6. BURDUNIUC, Olga, CATERENCIUC Natalia, et al. Ghid Managementul infecţiei cu Clostridioides difficile. Chișinău: Ministerul Sănătăţii, Muncii și Protecţiei Sociale al Republicii Moldova. Agenţia Naţională pentru Sănătate Publică, 2021, pp 23. [citat 07.07.2024] ISBN 978-9975-157-29-2.
7. CDC: Centers For Disease Control And Prevention. An official website of the United States government, ©1946 [ citat 09.07.2024]. Available: https://www.cdc.gov/covid/long-term-effects/index.html.
8. CDC: Centers For Disease Control And Prevention. An official website of the United States government, ©1946 [ citat 09.07.2024]. Available: https://www.cdc.gov/healthcare-associated-infections/php/haic-eip/cdiff.html.
9. COLLINS, J., AUCHTUNG, J.M. Control of clostridium difficile infection by defined microbial communities. Microbiology Spectrum [online]. 22 septembrie 2017, nr. 5(5), ISSN 2165-0497. https://doi.org/10.1128/microbiolspec.BAD-0009-2016
10. FINN, Elaine, et.al. Burden of Clostridioides difficile infection (CDI)-a systematic review of the epidemiology of primary and recurrent [online]. BMC Infectious Disease, 19 mai 2021 [citat 05.07.2024]. Available: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06147-y.
11. HAWES, Armani Minasian, et al. Clostridioides difficile testing and infection rates change during the COVID-19 pandemic [online]. PubMed Central, 23 mai 2021 [citat 05.07.2024]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141342/. https://doi.org/10.1016/j.anaerobe.2021.102384
12. LESSA, Fernanda C., et al. The burden of Clostridium difficile infection in the United States. In: The New England Journal of Medicine [online]. 2015, nr. 372(9), pp. 825-834 [citat 06.07.2024]. ISSN 1533-4406.
13. LUO, Yuying, et al. Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic. In: Infection Control Hospital Epidemiology [online]. 2020, nr. 42(9), pp. 1165 - 1166 [citat 06.07.2024]. ISSN 1559-6834. https://doi.org/10.1017/ice.2020.1223
14. MANEA, Eliza, et. al. Healthcare-associated Clostridioides difficile infection during the COVID-19 pandemic in a tertiary care hospital in Romania. In: Romanian Journal of Internal Medicine [online]. 2021, nr. 59(4), pp. 409-415 [citat 07.07.2024]. ISSN 2501-062X. https://doi.org/10.2478/rjim-2021-0020
15. MARRA, A.R., et al. Incidence and outcomes associated with Clostridium difficile infections: a systematic review and meta-analysis [online]. JAMA Network Open, 8 ianuarie 2020 [citat 07.07.2024]. Available: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2758401.
16. NELSON, Winnie W., et al. Health care resource utilization and costs of recurrent Clostridioides difficile infection in the elderly: a real-world claims analysis. In: Journal of Managed Care & Specialty Pharmacy [online]. 2021, nr. 27(7), pp. 828-838 . ISSN 2376-1032. https://doi.org/10.18553/jmcp.2021.20395
17. SANDHU, Avnish, et al. Clostridioides difficile in COVID-19 patients, Detroit, Michigan, USA, March-April 2020. In: Emergency Infectious Diseases [online]. 2020, nr. 26(9), pp. 2272-2274. ISSN 1080-6059. https://doi.org/10.3201/eid2609.202126
18. ZHANG, Dongmu, et al. Attributable healthcare resource utilization and costs for patients with primary and recurrent Clostridium difficile infection in the United States. In: Clinical Infectious Diseases [online]. 2018, nr. 66(9), pp. 1326-1332 . ISSN 1537-6591. https://doi.org/10.1093/cid/cix1021
19. ZHANG, Dongmei, et al. Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge. In: Journal of Korean Medicine Science [online]. 2023, nr. 38(15), ISSN 1598-6357. https://doi.org/10.3346/jkms.2023.38.e120
20. ZHOU, Yaya, et al. Linking the gut microbiota to persistent symptoms in survivors of COVID-19 after discharge. In: Journal of Microbiology [online]. 2021, nr. 59(10), pp 941-948. ISSN 1976-3794. https://doi.org/10.1007/s12275-021-1206-5
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