Интравитреальная химиотерапия по новым методикам в органосохранном лечении ретинобластомы

Abstract

A promising method of local CT is the intravitreal (IV) administration of cytostatics, of which melphalan is recognized as the most effective. IVCh allows the highest concentration of the chemotherapeutic agent to be obtained in the tissues of the eye with its minimum systemic concentration in the body, which reduces the risk of a general cytostatic side effect. 59 children were treated - 31 boys, 28 girls. The doses of melphalan and the time of administration were calculated according to tumor parameters. Indications have been developed for high-dose local chemotherapy (intravenous administration of melphalan at doses of 20 and 30 μg), which in combination with systemic chemoreduction and consolidation therapy has made it possible to save the eye in 92.3% of cases even with advanced T3 stages of retinoblastoma.