Use of 0.5% Timolol ophthalmic solution in the treatment of migrainous attacks
Keywords:
migraine headaches, autonomic nervous system, Timolol, beta-blockersAbstract
Migraine is often associated with photophobia, phonophobia, dizziness, sometimes vomiting, and fatigue. Usually, in the treatment of migraine attacks, non-steroidal anti-inflammatory drugs, ergot preparations, triptans are recommended. Determination of ophthalmic features in patients with migraine and study of the efficacy of Timolol 0.5% in migraine attack. The literature review presents the data of some authors who used ophthalmic drops sol.Timolol 0.5% in migraine patients. Cases of complete resolution of ophthalmoplegia and visual field deficiency have been reported in patients with hemiplegic migraine. This method of treatment may have a beneficial effect in preventing migraine attacks. Timolol eye drops 0.5% is an effective, well-tolerated, safe and simple remedy in crisis and preventive anti-migraine treatment.
References
1. Ha H, Gonzalez A. Migraine Headache Prophylaxis. Am Fam Physician. 2019 Jan 1;99(1):17-24.
2. Suzuki G, Kunikane E, Shinno K, Kozai S, Kurata M, Kawamura A. Ocular and Systemic Pharmacokinetics of Brimonidine and Timolol After Topical Administration in Rabbits: Comparison Between Fixed-Combination and Single Drugs. Ophthalmol Ther. 2020 Mar;9(1):115-125. https://doi.org/10.1007/s40123-020-00229-x
3. Ha H, Gonzalez A. Migraine Headache Prophylaxis. Am Fam Physician. 2019 Jan 1;99(1):17-24.
4. Huang J, Wilkins A. The Functional Network of the Visual Cortex Is Altered in Migraine. Vision (Basel). 2021 Nov 18;5(4):57. https://doi.org/10.3390/vision5040057
5. Hosp JA, Reisert M, von Kageneck C, Rijntjes M, Weiller C. Approximation to pain-signaling network in humans by means of migraine. Hum Brain Mapp. 2021 Feb 15;42(3):766-779. ElSherif M, Reda MI, Saadallah H, Mourad M. Eye movements and imaging in vestibular migraine. Acta Otorrinolaringol Esp (Engl Ed). 2020 Jan-Feb;71(1):3-8. English, Spanish. https://doi.org/10.1002/hbm.25261
7. Oskoui M, Pringsheim T, Holler-Managan Y, Potrebic S, Billinghurst L, Gloss D, Hershey AD, Licking N, Sowell M, Victorio MC, Gersz EM, Leininger E, Zanitsch H, Yonker M, Mack K. Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):487-499. https://doi.org/10.1212/WNL.0000000000008095
8 Lew C, Punnapuzha S. Migraine Medications. 2021 May 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. PMID: 31985952.
9. Ashina M, Terwindt GM, Al-Karagholi MA, de Boer I, Lee MJ, Hay DL, Schulte LH, Hadjikhani N, Sinclair AJ, Ashina H, Schwedt TJ, Goadsby PJ. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021 Apr 17;397(10283):1496-1504. https://doi.org/10.1016/S0140-6736(20)32162-0
10. Noseda R. et al. A neural mechanism for exacerbation of headache by light. In: Nature Neuroscience, 2010, vol. 13, p. 239-245. https://doi.org/10.1038/nn.2475
11. Peters GL. Migraine overview and summary of current and emerging treatment options. Am J Manag Care. 2019 Jan.
12. Chiam P.J. Topical beta-blocker treatment for migraine. In: Int Ophthalmol. 2012, vol. 32, nr.1, p. 85-88. https://doi.org/10.1007/s10792-012-9516-6
13. Migliazzo CV, Hagan JC 3rd. Beta blocker eye drops for treatment of acute migraine. Mo Med. 2014;111(4):283-288
14. Ishikawa H. et al. A pediatric case of ophthalmoplegic migraine with recurrent oculomotor nerve palsy. In: Jpn. J. Ophthalmol., 2000, vol. 44, nr. 5, p. 576. https://doi.org/10.1016/S0021-5155(00)00233-1
15. Bhagey J., James B. Topical timolol prevented migraine attacks. In: Eye (Lond). 2004, vol. 18, nr. 7, p. 751. https://doi.org/10.1038/sj.eye.6701303
16. Cossack M, Nabrinsky E, Turner H, Abraham A, Gratton S. Timolol eyedrops in the treatment of acute migraine attacks: a randomized crossover study. JAMA Neurol. 2018;75(8):1024-1025. https://doi.org/10.1001/jamaneurol.2018.0970
17. Kurian A, Reghunadhan I, Thilak P, Soman I, Nair U. Short-term Efficacy and Safety of Topical β-Blockers (Timolol Maleate Ophthalmic Solution, 0.5%) in Acute Migraine: A Randomized Crossover Trial. JAMA Ophthalmol. 2020 Nov 1;138(11):1160-1166. https://doi.org/10.1001/jamaophthalmol.2020.3676
18. Brar A. S., Brar M. K. Additional Considerations Regarding Timolol Eyedrops for Acute Treatment of Migraine //JAMA ophthalmology. - 2021. - Т. 139. - №. 8. - С. 920-920. https://doi.org/10.1001/jamaophthalmol.2021.1783
19. Katz BJ. Put a Drop of Timolol Into Each Eye and Call Me in the Morning. JAMA Ophthalmol. 2020 Nov 1;138(11):1166-1167. https://doi.org/10.1001/jamaophthalmol.2020.3837
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